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Rewarding for you and us Defeat Diabetes Foundation Defeat Diabetes
Foundation 150 153rd Ave, Suite 300 Madeira Beach, FL 33708 |
Obese and Diabetic Individuals Produce High Levels of Muscle Blocking ProteinBy Daniel H. RasoltPosted: Saturday, February 28, 2009
(Defeat Diabetes® News) -- A recent study has found that there is an additional obstacle in obtaining
good health for obese individuals, as well as type 2 diabetics, in that these
conditions lead to the production of a certain protein that inhibits muscle
growth. This troubling mechanism also appears to be a strong link between
pre-diabetes and full-blown type 2 diabetes.
The muscle blocking protein is known as myostatin. Myostatin is produced
within the muscles, but has the effect of limiting further muscle growth in
those areas, regardless of physical activity. Past research has shown that high
myostatin levels occur alongside starvation, as well as other "muscle-wasting"
conditions, such as AIDS. From a natural standpoint, the reason high myostatin
levels are associated with starvation is because having large muscle mass leads
to more rapid starvation, because the muscles require more calories. It's
believed by the researchers that the pre-diabetic condition, insulin resistance,
which is commonly found in obese individuals and is a prime characteristic of
type 2 diabetes as well, produces similar mechanisms in the body to those of
starvation, accounting for the following findings.
The current study has found that obese and type 2 diabetic individuals
produce abnormally large amounts of myostatin, creating an extra challenge when
attempting to change fat to muscle through necessary exercise. This is
particularly dangerous for diabetics, who need to control their blood sugar
levels in order to limit the damage created by the disease. Says lead author Dr.
Dustin Hittel, "the body reverses muscle production using myostatin. This is
particularly worrisome because losing muscle mass further erodes your ability to
control your blood sugar with exercise."
It's also noted that for insulin-resistant pre-diabetics, obese or not,
losing muscle mass is one of the primary stages in the development of full type
2 diabetes. While it is not known whether this lack of muscle mass is directly a
major cause for type 2 diabetes, the observation of diminishing muscle mass for
pre-diabetics should further motivate a healthier lifestyle to try and hold off
the dangerous disease.
Source: Defeat Diabetes Foundation: Hittel, Dustin. McSwiney, Don. Diabetes news release. February 2009. Daniel H. Rasolt writes for Defeat Diabetes® News. Read more of his original content articles. |
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