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Defeat Diabetes
150 153rd Ave,
Suite 300

Madeira Beach, FL 33708

Insulin Glargine Benefits Uncontrolled Type 2’s on Oral Meds Without Weight Gain

Posted: Thursday, January 18, 2007

Over 2000 type 2 patients lower their A1c 1.7 pts when insulin gargine is added to their oral therapy without weight gain.

This observational studied the long-term efficacy and safety of adding insulin glargine (LANTUS((R))) to support oral antidiabetic (OAD) treatment in patients with type 2 diabetes in everyday practice.

A 9-month, open-label, multicenter, observational study, with an optional 20-month extension phase, in which add-on insulin glargine therapy was initiated in 12,216 patients with type 2 diabetes inadequately controlled on OADs. The insulin glargine dose was adjusted at the physician's discretion, reflecting everyday practice. The main outcome measures were changes in HbA(1c), fasting blood glucose (FBG), insulin dose and body mass index (BMI). Results: At baseline, mean (+/- s.d.) age was 63.9 +/- 11.3 years; disease duration was >5 years in 47% of patients, 1-5 years in 39% of patients and <1 year in 10% of patients, while 4% of patients were newly diagnosed.

Addition of insulin glargine to OAD therapy led to reductions in mean HbA(1c) (-1.5% from 8.7%) and FBG (-69 mg/dl from 202 mg/dl) levels after 3 months, which were maintained after 9 months [HbA(1c): -1.7%; FBG: -71 mg/dl (-3.9 mmol/l)] without an increase in BMI. Similar glycemic control was observed after 20 months in the 2721 patients in the extension study.

Adverse drug reactions were documented in 26 patients (0.2%). Of 47 adverse events documented, 19 were due to hypoglycemia.

From the results it was concluded that, in everyday practice, patients with type 2 diabetes who are inadequately controlled on OADs benefit from add-on basal insulin treatment with insulin glargine as they demonstrate improved glycemic control without weight gain.

Diabetes Obes Metab. 2007 Jan;9(1):31-8


Source: Diabetes In Control: Diabetes Obes Metab. 2007 Jan;9(1):31-8

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