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Weight Loss Achieved by Two Lifestyle Interventions

Posted: Tuesday, January 08, 2013

"Until recently, rigorous trial evidence on effective, scalable treatment models in primary care practice has been lacking," according to a study by Jun Ma, MD, PhD, from the Department of Health Services Research, Palo Alto Medical Foundation Research Institute, and the Department of Medicine Stanford University School of Medicine, Stanford, California, and colleagues.

The Evaluation of Lifestyle Interventions to Treat Elevated Cardiometabolic Risk in Primary Care trial design is a 3-group, randomized study that compared both a coach-led, in-person weekly group intervention and a self-directed DVD intervention with usual care.

The interventions were adapted from those used in the landmark DPP trial, which produced a 58% reduction in the development of type 2 diabetes over the course of 3 years via modest weight loss.

In the current study, a total of 241 overweight or obese adults with prediabetes and/or metabolic syndrome were randomly assigned to 1 of the 3 groups for a 3-month intensive phase followed by a 12-month maintenance phase.

The same curriculum was delivered in both the coach-led and DVD formats, with both groups having the goal of gradual weight loss via incremental lifestyle changes. Both interventions included weight and physical activity goal-setting and motivational emails throughout the maintenance phase.

All study participants received standard medical care. Those randomly assigned to the usual care (control) group received no information regarding weight loss, although they were free to seek it out on their own.

At baseline, study participants were an average of nearly 53 years old, with a mean body mass index (BMI) of 32.0 kg/m 2. Slightly less than half (47%) were women, and the majority (78%) were non-Hispanic white. Most (87%) had metabolic syndrome, approximately 54% had prediabetes, and 41% had both.

The primary endpoint, change in BMI at 15 months, was significant for the 2 intervention groups compared with usual care: BMI dropped by 2.2 kg/m2 in the coach-led group (P < .001 compared with usual care) and by 1.6 kg/m2 with the DVD intervention (P = .02 compared with usual care) compared with just 0.9 kg/m2 with usual care.

Similarly, body weight also dropped significantly with the 2 interventions compared with baseline and with the usual care group. The coach-led group lost an average of 6.3 kg and the self-directed group lost 4.5 kg, whereas the usual care group lost 2.4 kg.

"The maximum weight loss achieved within the coach-led intervention was substantial...and similar in magnitude to that achieved by the DPP lifestyle intervention and other behavioral or drug-based weight-loss trials," Dr. Ma and colleagues write, adding, "Weight loss in the self-directed intervention was less pronounced...but noteworthy given its low resource requirements and high potential for dissemination."

Both intervention groups were also more likely to achieve the 7% DPP weight-loss goal, at 37.0% and 35.9% for in-person and DVD, respectively, compared with just 14.4% in the usual care group (P = .003 and .004, respectively).

Of the 81 participants in the usual care group, 15 said they used some type of weight loss program outside of the study compared with just 5 of the 79 in the coach-led intervention group and 3 of 81 in the DVD group. No study participants used weight-loss drugs or had weight-loss surgery.

"The net intervention effects were significant even though a higher proportion of usual care participants reported attending outside weight-loss programs during the study period," the authors note.

Statistically significant improvements in waist circumference and fasting plasma glucose were also seen with both interventions.

"Proven effective in a primary care setting, the 2 DPP-based lifestyle interventions are readily scalable and exportable for substantial clinical and public health impact," the authors write.

Source: http://www.diabetesincontrol.com/index.php?option=com_content&view=article&id=14034&catid=53&Itemid=8, Arch Intern Med. Published online December 10, 2012.

 
 
 
 
 
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