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Coenzyme Q10 Lowers Blood Pressure Substantially

Posted: Friday, April 20, 2007

Coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects.

The objective of this study by Australian researchers was to review all published trials of coenzyme Q10 for hypertension, assess overall efficacy and consistency of therapeutic action and side effect incidence. Meta-analysis was performed in 12 clinical trials (362 patients) comprising three randomized controlled trials, one crossover study and eight open label studies. In these trials the usual dose of coenzyme Q10 was 100 to 200 mg per day. The daily dose in some studies was as much as 360 mg. It is believed that the toxic dose is in excess of 3g per day.

They found: “In the randomized controlled trials (n=120), systolic blood pressure in the treatment group was 167.7 mm Hg before, and 151.1mm Hg after treatment, a decrease of 16.6mm Hg, with no significant change in the placebo group. Diastolic blood pressure in the treatment group was 103 (101–105) mm Hg before, and 94.8 (92.8–96.8) mm Hg after treatment, a decrease of 8.2 (6.2–10.2,) mm Hg, with no significant change in the placebo group. In the crossover study (n=18), systolic blood pressure decreased by 11 mm Hg and diastolic blood pressure by 8 mm Hg with no significant change with placebo. In the open label studies (n=214), mean systolic blood pressure was 162 (158.4–165.7) mm Hg before, and 148.6 (145–152.2) mm Hg after treatment, a decrease of 13.5 (9.8–17.1) mm Hg. Mean diastolic blood pressure was 97.1 (95.2–99.1) mm Hg before, and 86.8 (84.9–88.8) mm Hg after treatment, a decrease of 10.3 (8.4–12.3) mm Hg.”

The researchers concluded: “We conclude that coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects.”

Source: Diabetes In Control: Journal of Human Hypertension April 2007. 21, 297–306. doi:10.1038/sj.jhh.1002138. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials, F L Rosenfeldt, S J Haas, H Krum, A Hadj, K Ng, J-Y Leong and G F Watts.