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Conjugated Linoleic Acid (CLA) Supplementation Worsens Insulin Sensitivity And Fibrinogen Concentrations

Posted: Wednesday, October 06, 2004

CLA supplementation significantly increased fasting glucose concentrations (6.3%) and reduced insulin sensitivity.

.Researchers at the Department of Clinical Medicine, Trinity Centre for Health Sciences, and the Metabolic Research Unit, St James’s Hospital, both in Dublin, investigated the effect of CLA supplementation on markers of glucose and insulin metabolism, lipoprotein metabolism, and inflammatory markers of CVD in subjects with type 2 diabetes.

Thirty-two subjects with stable, diet-controlled type 2 diabetes received CLA in a randomized, double-blind, placebo-controlled trial. A 3-h 75-g oral-glucose-tolerance test was performed, and fasting plasma lipid concentrations and inflammatory markers were measured before and after the intervention.

Much to the researchers surprise the CLA supplementation significantly increased fasting glucose concentrations (6.3%) and reduced insulin sensitivity. Total HDL-cholesterol concentrations increased by 8%, The ratio of LDL to HDL cholesterol was significantly reduced. CLA supplementation reduced fibrinogen concentrations, but had no effect on the inflammatory markers of CVD (C-reactive protein and interleukin 6). Based on this small study it would be hard to recommend a nutrient with potentially adverse effects on type 2 diabetes patients.

Source: Diabetes In Control