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Cholesterol Drugs Work Best in Evening

Posted: Wednesday, October 29, 2003

Researchers from England studied 83 patients who were taking either 10 milligrams or 20 milligrams of simvastatin, otherwise known as Zocor. They were taking the drug for primary or secondary prevention of coronary heat disease, stroke, or peripheral vascular disease.

Patients were randomized to take the drug in the mornings or in the evenings. Fifty-seven patients completed the trial. Most manufacturers of statins recommend the drugs be taken at night, but doubt has been cast on whether that is the best time.

Researchers found when patients switched from taking their nighttime pill to the morning, there were significant increases in total cholesterol and LDL, or the bad, cholesterol.
Authors of the study write, "Simvastatin is probably best taken at night because concentrations of total cholesterol and of low density lipoprotein are significantly greater when it is taken in the morning. This finding has implications for compliance in preventing coronary heart disease."

Source: October News Article Index