Studies Identify Modifiable Factors Associated With Exceptionally Long Life

A healthy lifestyle during the early elderly years, including weight management, exercising regularly and not smoking, may be associated with a greater probability of living to age 90 in men, as well as good quality of life. 

This was reported, in the February 11 issue of Archives of Internal Medicine. A second article in the same issue finds that although some individuals survive to 100 years or beyond by avoiding chronic diseases, other centenarians live with such conditions for many years without becoming disabled.

Studies of twins have found that about one-fourth of the variation in human life span can be attributed to genetics, according to background information in the article. That leaves about 75 percent that could be attributed to modifiable risk factors.

They studied a group of 2,357 men who were participants in the Physician�s Health Study. At the beginning of the study, in 1981 to 1984, the men (average age 72) provided information about demographic and health variables, including height, weight, blood pressure and cholesterol levels and how often they exercised. Twice during the first year and then once each following year through 2006, they completed a questionnaire asking about changes in habits, health status or ability to do daily tasks.

A total of 970 men (41 percent) lived to age 90 or older. Several modifiable biological and behavioral factors were associated with survival to this exceptional age. �Smoking, diabetes, obesity and hypertension significantly reduced the likelihood of a 90-year life span, while regular vigorous exercise substantially improved it,� the authors write. �Furthermore, men with a life span of 90 or more years also had better physical function, mental well-being, and self-perceived health in late life compared with men who died at a younger age. Adverse factors associated with reduced longevity�smoking, obesity and sedentary lifestyle�also were significantly associated with poorer functional status in elderly years.

The researchers estimate that a 70-year-old man who did not smoke and had normal blood pressure and weight, no diabetes and exercised two to four times per week had a 54 percent probability of living to age 90. However, if he had adverse factors, his probability of living to age 90 was reduced to the following amount:

Source: Diabetes In Control: Arch Intern Med. 2008;168[3]:284-290, 277-283.