Read the current Defeat Diabetes® E-Lerts™ Newsletter

This website is certified by Health On the Net Foundation. Click to verify.
This site complies with the HONcode standard for trustworthy health information:
verify here.

Defeat Diabetes
150 153rd Ave,
Suite 300

Madeira Beach, FL 33708

New Drug Slows Diabetic Nerve Damage

Posted: Friday, July 28, 2006

A new drug in development looks very promising to treat diabetic nerve damage.

The drug, epalrestat, delays the progression of diabetic peripheral neuropathy, as the condition is called, and ameliorates its symptoms, according to a report in the journal Diabetes Care.

Epalrestat is an aldose reductase inhibitor, a class of compounds that have been developed to suppress a pathway thought to be involved in diabetic neuropathy, the authors explain, but most of these drugs have shown a weak benefit or unacceptable side effects.

Dr. Nigishi Hotta from Chubu Rosai Hospital, Nagoya, Japan and colleagues studied the efficacy and long-term safety of epalrestat in nearly 600 patients with mild diabetic neuropathy. The subjects were randomly assigned to the drug or to an inactive "placebo" for 3 years.

At follow-up, the epalrestat group showed no significant deterioration in nerve conduction velocity or vibration perception threshold, the team reports, whereas the placebo group experienced significant deterioration in both measures.

After 3 years, the epalrestat group had significantly less numbness of the upper and lower extremities, hypersensitivity, and cramping than did the control group, the researchers note, though there were no significant differences in extremity pain.
There were no severe adverse events, the team reports, and no adverse events were directly attributed to the long-term administration of epalrestat.

The researchers noted that the benefits of long-term treatment with epalrestat are particularly evident in patients with good blood sugar control.



Source: Diabetes In Control: Diabetes Care, July 2006

Join us on Facebook

Send your unopened, unexpired diabetes testing supplies to:

Defeat Diabetes Foundation
150 153rd Ave, Suite 300
Madeira Beach, FL 33708


DDF advertisement

 Friendly Banner

Friendly Banner
Analyze nutrition content by portion
DDF advertisement