Read the current Defeat Diabetes® E-Lerts™ Newsletter

This website is certified by Health On the Net Foundation. Click to verify.
This site complies with the HONcode standard for trustworthy health information:
verify here.

 
 
 
     
    
      
       
Defeat Diabetes
Foundation
150 153rd Ave,
Suite 300

Madeira Beach, FL 33708
  

Metformin Decreases BMI in Pre-Diabetic Adolescents

Posted: Sunday, February 14, 2010

Metformin XR (extended release formulation) appears to cause a decrease in body mass index (BMI) in non-diabetic obese adolescents when combined with a lifestyle intervention program.

Metformin XR (extended release formulation) -- a medication used to treat Type 2 diabetes -- appears to cause a small but significant decrease in body mass index (BMI) in non-diabetic obese adolescents when combined with a lifestyle intervention program.

Over the past 50 years, childhood obesity rates in the United States have tripled and 31.9 percent of children are now overweight or obese, according to background information in the article. Childhood obesity is associated with Type 2 diabetes mellitus, hypertension and a high risk for adult obesity and cardiovascular disease. Metformin hydrochloride is commonly used to treat obesity in non-diabetic adolescents, but there is not enough data available to confirm its efficacy as an obesity treatment.

Darrell M. Wilson, M.D., of Stanford University and the Lucile S. Packard Children's Hospital, Stanford, CA, and colleagues in the Glaser Pediatric Research Network Obesity Study Group randomly assigned 77 obese adolescents (ages 13 to 18) to a lifestyle intervention program (consisting of physical activity and diet) and either one daily dose of metformin XR (2,000 milligrams) (39 patients) or placebo (38 patients) for 48 weeks. Participants were monitored for an additional 48 weeks. 

"Metformin XR had a small but statistically significant impact on BMI over the initial 52 weeks of the study," the authors write. The average BMI increased by 0.2 in the placebo group and decreased by 0.9 in the metformin XR group. "The BMI difference between the groups persisted for 12 to 24 weeks after cessation of the study drug. Thereafter, the mean [average] BMI in the metformin group increased toward that in the control group."

"Metformin was safe and tolerated in this population. These results indicate that metformin may have an important role in the treatment of adolescent obesity," the authors conclude. "Longer-term studies will be needed to define the effects of metformin treatment on obesity-related disease risk in this population."

Source: Diabetes In Control: Arch Pediatr Adolesc Med. 2010;164[2]:116-123

 
 
 
 
 
Join us on Facebook
 
 
 

Send your unopened, unexpired diabetes testing supplies to:

Defeat Diabetes Foundation
150 153rd Ave, Suite 300
Madeira Beach, FL 33708

 

DDF advertisement
 

 Friendly Banner
 


Friendly Banner
 
 
 
Analyze nutrition content by portion
DDF advertisement