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New Weight-loss Enzyme in the Brain Identified

Posted: Wednesday, July 29, 2009

Reducing levels of a brain enzyme may curb appetite and boost energy, thereby helping people to control their weight, and reduce the risk of developing Type 2 diabetes, says a new study.

Prolylcarboxypeptidase (PRCP) regulates the alpha-melanocyte stimulating hormone (alpha-MSH), a body chemical that reduces hunger while revving up the body's energy levels. If PRCP enzyme is blocked, alpha-MSH levels stay high and keep appetite in check.

When researchers at Yale School of Medicine in New Haven, Conn., blocked PRCP in mice, the rodents lost weight, maintained their energy levels and reduced their risk of developing Type 2 diabetes, the team reported in the August issue of the Journal of Clinical Investigation.

Even after the mice ate a high-fat diet designed to simulate eating fast-food every day, the PRCP-blocked mice gained less weight than normal mice on a regular diet.

"Our research provides the first evidence that breaking down molecules in the brain that regulate metabolism is an important component of weight control," senior author Sabrina Diano, associate professor in Yale's departments of obstetrics, gynecology and reproductive sciences, and neurobiology, said in a news release from the university.

"Our findings provide a possible new target for the development of drugs to control metabolic disorders such as obesity and Type 2 diabetes," she added.

The researchers next plan to study how the body regulates PRCP, she said.

Source: Diabetes In Control: Yale School of Medicine in New Haven, Conn