Read the current Defeat Diabetes® E-Lerts™ Newsletter

This website is certified by Health On the Net Foundation. Click to verify.
This site complies with the HONcode standard for trustworthy health information:
verify here.

Defeat Diabetes
150 153rd Ave,
Suite 300

Madeira Beach, FL 33708

Type 2 Diabetes Tied to Brain Atrophy in the Elderly

Posted: Thursday, June 14, 2007

Type 2 diabetes has a negative effect on brain tissue volumes and regional cerebral perfusion in elderly patients, according to researchers. 
Senior investigator Dr. Vera Novak stated that, "Type 2 diabetes is associated with brain atrophy involving preferentially frontal and temporal lobes, and with impaired vascular reactivity.

In the May issue of Diabetes Care, Dr. Novak, of Beth Israel Deaconess Medical Center, Boston and colleagues hypothesize that the condition might be associated with microvascular disease. To investigate, they studied 26 diabetics, mean age of 61.6 years, and 25 comparable controls.

The diabetic group had significantly smaller global white and gray matter and larger cerebrospinal fluid (CSF) volumes than controls.

This was also true of white matter and CSF in the frontal region, of CSF in the temporal region, and of gray matter and CSF in the parieto-occipital region.

In addition, diabetes was associated with significantly reduced regional cerebral blood flow and CO2 reactivity. Hypoperfusion in the frontal region was significantly associated with gray matter atrophy, and higher glycosylated hemoglobin was associated with significantly lower cerebral blood flow and greater CSF within the temporal region.

The researchers note that uncontrolled diabetes may contribute to such problems. "These findings may have clinical implications for development of cognitive impairment, executive dysfunction and balance problems in people with diabetes," Dr. Novak said.

"New preventive and therapeutic strategies improving vascular reactivity and preventing brain atrophy are needed," she concluded.

Source: Diabetes In Control: Diabetes Care 2007;30:1193-1199

Join us on Facebook

Send your unopened, unexpired diabetes testing supplies to:

Defeat Diabetes Foundation
150 153rd Ave, Suite 300
Madeira Beach, FL 33708


DDF advertisement

 Friendly Banner

Friendly Banner
Analyze nutrition content by portion
DDF advertisement