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Research » Beta Cells

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Circadian Clock in Pancreas Linked to Diabetes
Posted: Sunday, June 27, 2010
For the first time, researchers at Northwestern University have found that there also exists a circadian clock in the pancreas, which regulates the production of insulin, and that a fault in this clock could eventually cause diabetes.

Discovery of Important New Player in Diabetes Onset
Posted: Sunday, June 20, 2010
A research team led by a La Jolla Institute scientist has unmasked a previously unknown cellular player, which is critical to proper insulin secretion.

Cells in Pancreas Can Spontaneously Change into Insulin-Producing Cells
Posted: Sunday, April 18, 2010
Alpha cells in the pancreas, which do not produce insulin, can convert into insulin-producing beta cells, advancing the prospect of regenerating beta cells as a cure for Type 1 diabetes.

Study Finds Insulin Regulates Beta Cell Function in Healthy Humans
Posted: Sunday, February 28, 2010
Finding by Joslin scientists may aid in understanding how insulin production eventually goes wrong in Type 2 diabetes.

Key to Reversing Type 1 Diabetes Discovered
Posted: Sunday, February 14, 2010
Doctors at Eastern Virginia Medical School's Strelitz Diabetes Center have been stalking the culprit responsible for Type 1 diabetes. Now, they are one step closer.

New GLP-1 Medication Lowers A1c Six Months after Treatment Stopped
Posted: Sunday, February 07, 2010
Transition Therapeutics announces results of a Phase 2 study of TT-223 (GLP-1 Cpd + Gastrin) in Type 2 diabetes patients. The results show that beta-cells can possibly be generated and/or restored. After a 10 week trial the drug was stopped and 6 months later, the A1c had dropped by 1.13 points.

Joslin Identifies Source of Beta Cell Damage
Posted: Sunday, January 17, 2010
Scientists at the Joslin Diabetes Center, Boston, MA, led by Principal Investigator Robert Stanton, M.D., have discovered that high blood glucose levels damage a key enzyme that guards insulin-producing beta cells. Their surprising finding raises hopes of finding drugs that protect the enzyme, and thus the beta cells and their insulin production. The discovery focuses on a cellular process known as "oxidative stress."

Relieving Stress on Insulin-producing Cells May Prevent Diabetes
Posted: Sunday, January 03, 2010
Cells in your body are constantly churning out poisonous forms of oxygen (oxidants) and mopping them up with a countervailing force of proteins and chemicals (anti-oxidants). This balancing act of oxidative stress is particularly likely to go haywire in beta cells, the insulin-producing cells that malfunction and then start to die off in Type 2 diabetes.

Anakinra Provides Sustained Benefits for Diabetes
Posted: Wednesday, September 30, 2009
Months after withdrawal of the interleukin-1 receptor antagonist (IL-1Ra) anakinra, patients with Type 2 diabetes still show improvements in beta cell function, hemoglobin A1c levels, and markers of systemic inflammation, according to a new published report.

Diabetes Vaccine Diamyd® Shows Reduction or Halting Destruction of Beta-Cells 4 Years Later
Posted: Wednesday, September 09, 2009
Diamyd Medical announced last week that the company's 4-year follow-up of Type 1 diabetes patients included in the company's Phase II study shows a clear positive trend.

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