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Abnormal Fasting Plasma
Glucose Linked With Ischemic Stroke
posted October 21, 2004
Ischemic stroke risk increases by
2.82 times when the fasting blood glucose is greater than 140 mg/dL
There is a J-shaped association between fasting plasma glucose and incident
ischemic cerebrovascular events in subjects with pre-existing atherothrombotic
disease, researchers report.
"Rates increase for fasting plasma glucose levels > 100 mg/dL and also for those
with low fasting glucose levels," according to their report in the October issue
of Stroke.
Dr. David Tanne, of Chaim Medical Center, in Tel-Hashomer, Israel, and examined
the association between various fasting plasma glucose levels and the risk of
incident ischemic stroke in 13,999 patients with documented coronary heart
disease.
Medical histories were obtained, and plasma glucose and lipids were assessed at
baseline. A total of 1037 patients were identified with ischemic cerebrovascular
disease during 6 to 8 years of follow-up. Ischemic stroke or transient ischemic
attack was confirmed in 576.
A positive association was observed between increasing fasting glucose levels
and increasing age, male gender, body mass index, hypertension, total
cholesterol, and triglycerides. Increasing fasting glucose was inversely
associated with high-density lipoprotein cholesterol and percent high-density
lipoprotein of total cholesterol.
After adjusting for potential confounders, the odds ratio of ischemic
cerebrovascular disease were 1.47 for fasting glucose less than 80 mg/dL and
2.82 for greater than 140 mg/dL, compared to those with levels of 90 to 99 mg/dL.
"Relative odds in patients without a diagnosis of diabetes mellitus and for the
end-point ischemic stroke/transient ischemic attack exhibited similar trends,"
the researchers write.
Source: Diabetes In Control.com:
Stroke 2004;35:2351-2355.
October 2004 News Article Index
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