The findings suggest that factors that control stomach volume, independent of body size, are potential targets in fighting obesity, according to researchers.

The investigators found that compared with normal-weight adults, those who were overweight or obese took longer to feel satiated at mealtime. Similarly, those whose empty stomachs were larger needed more calories to feel completely full.

It was not, however, merely a matter of bigger people having bigger stomachs, according to findings published in the journal Gastroenterology.

Instead, fasting gastric volume--the size of a person's empty stomach--was related to a feeling of fullness independent of body size, researchers at the Mayo Clinic College of Medicine in Rochester, Minnesota, found.

Their study included 134 healthy volunteers who, after an overnight fast, drank a liquid meal until they reached maximum satiation. Their stomach volume before and after eating was measured through non-invasive imaging.

The researchers found that both body mass index (BMI) and fasting gastric volume were independently linked to the time it took participants to become full.

The fact that BMI and stomach size did not go hand-in-hand is "somewhat surprising," study author Dr. Michael Camilleri told Reuters Health, and illustrates that stomach volume is determined by more than mere body size.

Moreover, according to Camilleri, the study suggests that factors governing stomach volume might help predispose people to obesity and could serve as targets for weight-control tactics.

These control mechanisms could range from eating patterns--such as whether a person eats small meals throughout the day or tends to binge--to hormones, to the nerves that control stomach contraction and relaxation, Camilleri noted.

Addressing these factors might then alter how long it takes a person to feel full. For example, Camilleri explained, changes in diet or patterns of food intake might do the job, as could medications that act on the nerves or hormones that control stomach volume, or other procedures or devices that change gastric volume.

Before any of this becomes reality, he noted, further research is needed to pinpoint the critical controls involved in determining stomach volume.

Source: Yahoo News: Reuters Health: Gastroenterology, February 2004.

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