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New Screening Techniques
To Distinguish Type 1 and Type 2 Diabetes
posted September 08, 2004
Serum concentrations of adiponectin
and leptin can aid in discriminating between diabetes type 1 and type 2 in
adolescents and children.
Dr. Mark Atkinson, senior investigator feels this is very important, because of
"the recent explosion in rates of type 2 diabetes observed in children and
adolescents. We need better markers to distinguish this disease from cases of
type 1 diabetes, a disorder we historically have linked to this age group."
Dr. Atkinson of the University of Florida, Gainesville and colleagues studied 41
young subjects with type 1 diabetes, 17 with type 2 diabetes and 43 controls.
Serum adiponectin concentrations were similar in type 1 diabetics and controls,
but type 2 diabetics showed significantly lower levels.
Conversely, subjects with type 2 diabetes had significantly elevated levels of
leptin compared to those in type 1 diabetics and in control subjects.
Moreover, say the investigators, evaluation of adiponectin-to-leptin ratios
revealed a "striking difference" between children with type 1 and type 2
diabetes.
"Our findings," Dr. Atkinson concluded, should not only help differentiate the
conditions "but in addition, may provide clues to the mechanisms that underlie
each disorder and point to targets aimed at preventing diabetes."
Source: Diabetes In Control.com: Diabetes Care 2004;27:2010-2014.
September 2004 News Article Index
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