About Diabetes
Complications
Warning Signs
Screening Test
Donate Now
E-Lerts™
Index
Latest News
Diabetes Terms
Health & Fitness
Online Press Center
Increased Risk For Impaired Glucose Tolerance and
Metabolic Syndrome For Relatives of Type 2 Diabetics
posted 03/18/04
A high proportion of first-degree relatives of patients with
type 2 diabetes will develop impaired or diabetic glucose tolerance in
association with multiple other metabolic syndrome characteristics.
Mounting evidence suggests that type 2 diabetes is not just a disorder of
glucose metabolism; the combination of diabetic glucose tolerance, insulin
resistance, and increased weight is thought to play a major pathophysiological
role in the "metabolic syndrome", a clustering of cardiovascular risk factors.
Moreover, this clustering may not only occur in those with diabetic glucose
tolerance, but also in persons with impaired glucose tolerance.
Michael A. Nauck, of the Diabetes Center Bad Lauterberg, Harz, Germany, and
colleagues performed a 25-year follow-up study to characterize the association
of oral glucose tolerance with components of the metabolic syndrome in subjects
with a clear genetic burden for developing type 2 diabetes.
The original cohort included 686 first-degree relatives of type 2 diabetes
patients followed in a long-term study for the development of impaired glucose
tolerance or diabetes. The present analysis included 135 survivors from this
cohort who were available for the study and did not have known type 2 diabetes.
All participants underwent a 75-g oral glucose tolerance test and were evaluated
for anthropomorphic data, blood pressure, insulin and C-peptide concentrations,
and parameters of lipid metabolism.
Of the 135 participants, 71 were found to have normal glucose tolerance, 22 had
impaired glucose tolerance, and 42 had diabetic glucose tolerance as classified
by WHO criteria. Impaired and diabetic glucose tolerance were significantly
associated with advanced age (P = .001), increased weight (P =
.005), high waist-hip ratio (P = .001), systolic hypertension (P =
.031), elevated basal insulin (P < .001) and C-peptide concentrations (P
< .001), elevated free fatty acid levels (P < .001) and triglycerides (P
= .017), and low HDL-cholesterol (P < .003). No associations were found
with total and LDL-cholesterol.
As a rule, abnormalities in 1 parameter were associated with significant
differences in a number of other parameters belonging to the metabolic syndrome,
but an association between dyslipidemia and hypertension was less apparent. The
presence of 3 or more abnormalities was associated with significant
deteriorations in all other components of the metabolic syndrome analyzed.
"The association of type 2 diabetes with other cardiovascular risk factors makes
it necessary to include preventive measures regarding these characteristics in
standard patient education programs," the researchers propose. In addition, they
suggest that a modified perception of type 2 diabetes as part of a metabolic
syndrome rather than an isolated derangement of glucose metabolism may aid in
the identification of candidate genes for this disease.
Source: Diabetes In Control.com: Acta Diabetol 2003 Dec;40:4:163-72.
|
|
|
To be sure and come back to keep up with all the
Latest News and important information for diabetics - and to remind
yourself to manage and control your diabetes, click the yellow link
below
to add a small icon of our Defeat Diabetes® "Torch"
logo to your desktop. All you need to do after that is
click on the "Torch" to open our website.
Remember, we're here for you!
Translate this page into Spanish using FreeTranslation.com. © Copyright 2001 - 2004, Defeat Diabetes Foundation, Inc., All Rights Reserved |
We
subscribe to the HONcode principles