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Periodontal Disease
Predicts Mortality in Diabetics
posted January 24,
2005
Those with severe periodontal
disease had a 28.4 % death rate and those with no or little periodontal disease
had a 3.7% death rate.
The results of a study published in the January issue of Diabetes Care
suggest that periodontal disease is strongly predictive of mortality from
ischemic heart disease and diabetic nephropathy in Pima Indians with type 2
diabetes.
In a prospective longitudinal study, Dr. Robert G. Nelson, of the National
Institute of Diabetes and Digestive and Kidney Disease, Phoenix, Arizona, and
colleagues examined the effect of periodontal disease on overall and
cardiovascular disease mortality in 628 Pima Indians 35 years of age or older
with type 2 diabetes.
The team used panoramic radiographs and clinical dental examinations to classify
periodontal abnormality as none, mild, moderate, or severe. Overall, nearly 60%
of the subjects had severe periodontal disease. Of these, 263 (70%) were
edentulous.
A total of 204 subjects died during a median follow-up of 11 years. Forty-four
of the 54 cardiovascular disease-related deaths were attributed to ischemic
heart disease. Twenty-eight of the 35 diabetes-related deaths were attributed to
diabetic nephropathy.
"The age- and sex-adjusted death rates for all natural causes expressed as the
number of deaths per 1000 person-years of follow-up were 3.7 for no or mild
periodontal disease, 19.6 for moderate disease, and 28.4 for severe periodontal
disease," they report.
Periodontal disease was predictive of mortality from ischemic heart disease (p
trend = 0.04) and diabetic nephropathy (p trend < 0.01). No association was
observed between death rates from other causes and periodontal disease.
"Periodontal disease is a major public health burden in Pima Indians, and it is
a strong predictor of death from cardiorenal disease in those with type 2
diabetes," the researchers conclude.
January 2005 News Article Index
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