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Low Testosterone Levels in Men Predicts Metabolic
Syndrome, Diabetes
posted 05/29/04
Middle-age men with low levels of testosterone or sex
hormone-binding globulin, or both, are at risk for the development of the
metabolic syndrome and diabetes.
A multicenter team led by Dr. David E. Laaksonen of Kuopio University Hospital
in Kuopio, Finland reports on its long-term follow-up of 702 middle-age men who
were participating in a population-based cohort study. At the start of the
study, none of the men had diabetes or the metabolic syndrome. After 11 years,
however, 147 men had the metabolic syndrome and 57 had diabetes.
Low levels of total testosterone and sex hormone binding globulin were
independent predictors of the metabolic syndrome and diabetes, the authors said.
Specifically, after adjustment for age, the odds ratios for development of the
metabolic syndrome for men with lowest-quartile hormone levels were 2.3 (for low
testosterone), 1.7 (for low calculated free testosterone), and 2.8 (for low sex
hormone-binding globulin).
Odds ratios for development of diabetes for men with lowest-quartile hormone
levels were 2.3 (for low testosterone), 1.7 (for low calculated free
testosterone), and 4.3 (for low sex hormone-binding globulin). The associations
were not altered by cardiovascular disease, smoking, alcohol intake, or
socioeconomic status. After adjustment for factors related to insulin
resistance, the associations "remained significant, except for free
testosterone," according to the study.
The researchers conclude: "Hypoandrogenism is an early marker for disturbances
in insulin and glucose metabolism that may progress to the metabolic syndrome or
frank diabetes and may contribute to their pathogenesis."
Source: Diabetes In Control.com: Diabetes Care 2004;27:1036-1041.
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