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Leptin Alters Brains -
Eases Cravings of People with Obesity Gene
posted May 12,
2005
A magnetic resonance imaging (MRI)
study finds that the protein hormone leptin promotes development of gray matter
in the part of the brain that regulates cravings and the ability to monitor
personal behavior.
After receiving leptin replacement therapy, research subjects with a recessive
mutation in the obesity (ob) gene – a population both deficient in Leptin and
morbidly obese – lost about half of their body weight while regulating their own
food intake.
The findings suggest Leptin may play a role in modulating personal behavior
and perhaps food cravings. Leptin is a protein hormone that plays an important
role in regulating body weight, metabolism and reproductive function.
Researchers took MRI scans of research subjects’ brains prior to beginning
leptin replacement treatment, and again at six and 18 months after treatment
began.
Source: Diabetes In Control.com: Journal of Clinical
Endocrinology & Metabolism (May 2005).
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