People with isolated IFG were more resistant to insulin than people with IGT, and that people with isolated IGT showed a greater deficiency in the early and late stages of insulin secretion.
Investigators for the Risk Factor in Impaired Glucose Tolerance for Atherosclerosis and Diabetes (RIAD) study compared insulin secretion abnormalities and insulin resistance related to isolated impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), two risk factors for type 2 diabetes. People at high risk of type 2 diabetes underwent a 75-gram oral glucose tolerance test and were monitored at half-hourly intervals for 2 hours for specific insulin, proinsulin, free fatty acids and C peptide.
After adjusting for sex, age and body mass index, nondiabetic participants with hyperglycemia were found to be at higher risk of cardiovascular disease than people with normal glucose tolerance. Analysis of the importance of insulin resistance and insulin secretion abnormalities demonstrated that for participants with IFG, insulin resistance was the cause of 28.4% of the difference from people with normal glucose tolerance, and in people with IGT, the main variance resulted from abnormalities in insulin secretion (31.1%).
It was concluded that people with isolated IFG were more resistant to insulin than people with IGT, and that people with isolated IGT showed a greater deficiency in the early and late stages of insulin secretion. This suggests that alternative approaches are needed for these patients in the primary prevention of type 2 diabetes.
Source: Diabetes In Control Dot Com: Diabetes Care 2003;26:868-874.
Home -
Table of
Contents -
Donate Now -
About
Diabetes -
Warning Signs -
Complications
- Screening Test -
Diabetes
Terms -
Site Search -
Meet
Mr. Diabetes® -
Wake Up And
Walk® Tour -
Latest News -
Headlines
& News Stories -
Health
& Fitness -
About Us -
FAQ
- Research Form -
-
Message Board -
Privacy
Policy -
Legal Notices
-
How to Contact Us
-
Comments form -
Suggestion Form
- Our E-Mail
Addresses -
Our Address and Phone
Numbers -
Links
-
Contact Us