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Liver Tests Required
Less Often For Actos or Avandia
posted September 08, 2004
Liver enzymes no longer recommended
every 2 months.
The first glitazone, Rezulin, caused serious hepatotoxicity. Due to this scare,
liver enzymes were recommended every 2 months for the first year for Actos and
Avandia.
But they don't have the side chain suspected to cause liver toxicity...and now
with years of experience they appear much safer. The new schedule recommends
testing liver enzymes prior to starting therapy...and periodically thereafter.
Recommend discontinuing Actos or Avandia if liver enzymes rise to greater than 3
times normal...or if jaundice occurs.
Source: Diabetes In Control.com: Hosp Pharm 2001;36(4):456-62.
September 2004 News Article Index
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