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New Discovery in
Preventing Diabetic Complications
posted September 07, 2004
Controlling a specific protein
produced by the body, known as a cytokine, reduces the expression of other
molecules and helps control inflammation.
A new study sheds light on the response to infection in people with type 2
diabetes. These individuals develop diabetes associated with obesity. Findings
from this study revealed that controlling a specific protein produced by the
body, known as a cytokine, reduces the expression of other molecules and helps
control inflammation. This is significant because many complications associated
with diabetes trigger an inflammatory response.
Tumor necrosis factor (TNF), a type of cytokine, can cause inflammation and
damage in soft tissue infections, bite wounds and in periodontal disease. In a
recent study published in the Journal of Investigative Dermatology, two groups
of lab mice, one normal, the other diabetic, were injected with anaerobic
bacteria, a germ present in “approximately one-third of bite wounds and …
associated with the formation of abscesses and with relatively serious
infections,” to determine how type 2 diabetes affects the inflammatory response
in surrounding tissue. Results from the tests demonstrated that the presence of
diabetes prolongs inflammation. Following infection, the normal mice were able
to rapidly resolve the ensuing inflammation within three days whereas the
diabetic mice could not.
“It may be particularly important in diabetics to consider the impact that
prolonged inflammation might have on the course of events,” states contributing
author Dr. Dana T. Graves, currently a Professor in the Department of
Periodontology and Oral Biology at the Boston University School of Dental
Medicine. According to the study, diabetics are particularly susceptible to the
detrimental effects of infection associated with inflammatory cytokines.
Further, inflammation can often be a precursor to complications such as
cardiovascular disease and poor wound healing. Dr. Graves concludes, “If excess
TNF in diabetics is inhibited, the tendency for prolonged inflammation is
reduced.”
Source: Diabetes In Control.com: Journal of Investigative
Dermatology, Aug 2004.
September 2004 News Article Index
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