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Diabetes Protects Against Prostate Cancer
posted 06/03/04
New findings provide something positive about having diabetes
Findings from a new study provide further evidence that men
with diabetes mellitus have a reduced risk of prostate cancer. After controlling
for potential confounders, the authors found that diabetes was associated with a
36% reduction in the risk of prostate cancer.
In theory, because low insulin levels are linked to low levels of testosterone,
diabetes should protect against prostate cancer, a malignancy stimulated by high
androgen levels, explain Dr. K. Zhu, from the US Military Cancer Institute in
Washington, DC, and colleagues in the May 15th issue of the American Journal of
Epidemiology. Yet previous studies examining the association have yielded
conflicting results.
To further investigate the diabetes/prostate cancer link, the researchers used
data from the Physicians' Health Study to perform a case-control analysis. The
study group included 1110 case and control subjects who were followed from 1982
to 1995.
In addition to the presence of diabetes being associated with a reduction in
prostate cancer risk, duration of diabetes also decreased the cancer risk.
Diabetes was tied to a decreased risk of stage B through D prostate cancer, but
not stage A disease.
"The results contribute to the understanding of factors that may delay prostate
cancer progression and are helpful for developing therapeutic and preventive
interventions," the investigators note. "Large studies with similar results will
help to solidify the present findings."
Source: Diabetes In Control.com: Am J Epidemiol
2004;159:978-982.
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