Even mild increase of
homocysteinemia play an important role in the progression of atherosclerosis,
either in coronary or peripheral arteries.
Accelerated atherosclerosis is
common in diabetes mellitus, although its extent is not always related to its
strong association with classical cardiovascular risk factors.
Diabetic patients, especially
with type 2 diabetes, are prone to cardiovascular disease which is the leading
cause of death in this population. Recent clinical studies among general
population have shown that an even mild increase of homocysteinemia play an
important role in the progression of atherosclerosis, either in coronary or
peripheral arteries.
An increasing amount of in
vitro data is providing evidence that excess of homocysteine has a toxic effect
on the arterial wall. This aminoacid thus appears to be not only a risk marker
but also an emerging cardiovascular risk factor. The measurement of plasma
homocysteine contributes to the identification, among the diabetic population,
of patients at high cardio-vascular risk, with the aim of improving their global
management.
Moreover the addition of group B vitamins provides an easy and low-cost treatment to lower hyperhomocysteinemia.
Source: Diabetes In Control.Com: Diabetes Metab 2002 Dec;28(6):510-5.
January 2003 News Article Index
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